Journal
FITOTERAPIA
Volume 142, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2020.104527
Keywords
Mallotus oppositifolius; Euphorbiaceae; Phloroglucinols; Antibacterial
Categories
Funding
- Agence Universitaire de la Francophonie -AUF [CE/DG/79-16/2016]
- World Academy of Science - TWAS [3240299157/2017]
- Organisation for the Prohibition of Chemical Weapons - OPCW [L/ICA/ICB/214571/18]
- World Academy of Science (TWAS) [AC_G-FR 3240303654]
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From the ethno-medicinally used leaves of Mallotus oppositifolius, four acylphloroglucinol derivatives, namely Acronyculatin SeU (1-3) and Mallotojaponin D (4) were isolated along with seven known compounds (5-11). Structures were elucidated by comprehensive spectroscopic analyses and HRMS data. Absolute configurations were assigned by careful comparison of their specific optical rotation with those of closely related compounds. Compounds 1, 2, 6 and 11 demonstrated inhibitory activity against the bacterial strains E. coli, S. aureus, S. typhi, P. aeruginosa with minimum inhibitory concentration (MIC) values ranging from 3.125 to 50 mu g/ml.
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