Journal
FEBS JOURNAL
Volume 288, Issue 1, Pages 99-110Publisher
WILEY
DOI: 10.1111/febs.15338
Keywords
fruit fly; gene regulatory network; pigmentation; Quartz-Seq; regulatory circuit
Categories
Funding
- NBRP Genome Information Upgrading Program (Drosophila)
- KAKENHI [18J20452, 17K19427, 18H02486]
- Yamada Science Foundation
- NIBB Collaborative Research Program [15-835, 16-426, 17-423, 18402, 19-403]
- Grants-in-Aid for Scientific Research [18J20452, 17K19427, 18H02486] Funding Source: KAKEN
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The study explored the genetic and molecular bases of the novel wing pigmentation pattern of a polka-dotted fruit fly, revealing that multiple gene regulatory networks, signaling pathways, and effector genes may have contributed to the emergence of this new trait.
How evolutionary novelties have arisen is one of the central questions in evolutionary biology. Preexisting gene regulatory networks or signaling pathways have been shown to be co-opted for building novel traits in several organisms. However, the structure of entire gene regulatory networks and evolutionary events of gene co-option for emergence of a novel trait are poorly understood. In this study, to explore the genetic and molecular bases of the novel wing pigmentation pattern of a polka-dotted fruit fly (Drosophila guttifera), we performed de novo genome sequencing and transcriptome analyses. As a result, we comprehensively identified the genes associated with the pigmentation pattern. Furthermore, we revealed that 151 of these associated genes were positively or negatively regulated by wingless, a master regulator of wing pigmentation. Genes for neural development, Wnt signaling, Dpp signaling, and effectors (such as enzymes) for melanin pigmentation were included among these 151 genes. None of the known regulatory genes that regulate pigmentation pattern formation in other fruit fly species were included. Our results suggest that the novel pigmentation pattern of a polka-dotted fruit fly might have emerged through multistep co-options of multiple gene regulatory networks, signaling pathways, and effector genes, rather than recruitment of one large gene circuit.
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