Journal
FEBS JOURNAL
Volume 288, Issue 1, Pages 325-353Publisher
WILEY
DOI: 10.1111/febs.15341
Keywords
cochlea; common marmoset; inner ear; primate
Categories
Funding
- Japanese government MEXT KAKENHI [18H04065, 19H05473, 18K16856]
- Keio Medical Association
- Keio University Medical Science Fund
- Society for Promotion of International Oto-Rhino-Laryngology (SPIO)
- Keio Gijuku Academic Development Funds
- Mitsubishi Tanabe
- Takeda Science Foundation
- Grant for Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS)
- Grants-in-Aid for Scientific Research [18H04065, 18K16856] Funding Source: KAKEN
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Cochlear development is a complex process crucial for understanding congenital hearing loss and regenerative medicine. The common marmoset, a New World monkey species, is suggested as an effective alternative for studying primate cochlear development, with similarities to humans and mice in general stages but differences in certain protein expression related to supporting cell processes and neuronal development. Human fetal samples for primate-specific cochlear development studies are rare, particularly for late developmental stages.
Cochlear development is a complex process with precise spatiotemporal patterns. A detailed understanding of this process is important for studies of congenital hearing loss and regenerative medicine. However, much of our understanding of cochlear development is based on rodent models. Animal models that bridge the gap between humans and rodents are needed. In this study, we investigated the development of hearing organs in a small New World monkey species, the common marmoset (Callithrix jacchus). We describe the general stages of cochlear development in comparison with those of humans and mice. Moreover, we examined more than 25 proteins involved in cochlear development and found that expression patterns were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Human fetal samples for studies of primate-specific cochlear development are extremely rare, especially for late developmental stages. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development.
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