Journal
FEBS JOURNAL
Volume 287, Issue 16, Pages 3396-3398Publisher
WILEY
DOI: 10.1111/febs.15304
Keywords
adipokine; Drosophila; fat body; hemocyte; NimB5
Categories
Funding
- French State fund [ANR-10-LABX-0030-INRT, ANR-10-IDEX-0002-02]
- INSERM
- CNRS
- UDS
- Ligue Regionale contre le Cancer
- Hopital de Strasbourg
- ARC
- CEFIPRA
- ANR
- CNRS/University LIA Calim
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The development and the maintenance of an efficient immune system represents a considerable metabolic investment for the organism. Ramond et al. have characterized a new molecular and cellular pathway, inhibiting the immune system in poor diet conditions in the Drosophila larva. Low nutrient conditions lead to the secretion of the adipokine NimB5 by the fat body, which inhibits the proliferation of the immune cells, hence preventing the exhaustion of the resources.
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