Journal
FEBS JOURNAL
Volume 287, Issue 13, Pages 2647-2663Publisher
WILEY
DOI: 10.1111/febs.15308
Keywords
apoptosis; autophagy; BCL-2; cancer; caspase; ferroptosis; mPTP; necroptosis; pyroptosis
Categories
Funding
- NIGMS NIH HHS [F32 GM095253] Funding Source: Medline
- NINDS NIH HHS [R01 NS037402, RO1 NS037402] Funding Source: Medline
Ask authors/readers for more resources
Apoptosis is a highly regulated form of cell death that is required for many homeostatic and pathological processes. Recently, alternative cell death pathways have emerged whose regulation is dependent on proteins with canonical functions in apoptosis. Dysregulation of apoptotic signaling frequently underlies the pathogenesis of many cancers, reinforcing the need to develop therapies that initiate alternative cell death processes. This review outlines the convergence points between apoptosis and other death pathways with the purpose of identifying novel strategies for the treatment of apoptosis-refractory cancers. Apoptosis proteins can play key roles in the initiation, regulation, and execution of nonapoptotic death processes that include necroptosis, autophagy, pyroptosis, mPTP-mediated necrosis, and ferroptosis. Notably, recent evidence illustrates that dying cells can exhibit biochemical and molecular characteristics of more than one different type of regulated cell death. Thus, this review highlights the amazing complexity and interconnectivity of cell death processes and also raises the idea that a top-to-bottom approach to describing cell death mechanisms may be inadequate for fully understanding the means by which cells die.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available