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Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors
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CANCER RESEARCH (2011)
Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors
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JOURNAL OF MEDICINAL CHEMISTRY (2011)
Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis
Fabio Pacchiano et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Interfering with pH regulation in tumours as a therapeutic strategy
Dario Neri et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Structural Studies of β-Carbonic Anhydrase from the Green Alga Coccomyxa: Inhibitor Complexes with Anions and Acetazolamide
Shenghua Huang et al.
PLOS ONE (2011)
Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations
Jason Wagner et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range
Alfonso Maresca et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors
Balendu Sankara Avvaru et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II
Alfonso Maresca et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency
Fabio Pacchiano et al.
CHEMICAL COMMUNICATIONS (2010)
The Coumarin-Binding Site in Carbonic Anhydrase Accommodates Structurally Diverse Inhibitors: The Antiepileptic Lacosamide As an Example and Lead Molecule for Novel Classes of Carbonic Anhydrase Inhibitors
Claudia Temperini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Polyamines Inhibit Carbonic Anhydrases by Anchoring to the Zinc-Coordinated Water Molecule
Fabrizio Carta et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins
Alfonso Maresca et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Selective Inhibition of Carbonic Anhydrase IX Decreases Cell Proliferation and Induces Ceramide-Mediated Apoptosis in Human Cancer Cells
Fabio Cianchi et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
Acetazolamide and midazolam act synergistically to inhibit neuropathic pain
Marina Asiedu et al.
PAIN (2010)
Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors
Alfonso Maresca et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX
Vincenzo Alterio et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II
Esra Bayram et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Carbonic anhydrase activators: Kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV
Claudia Temperini et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Carbonic anhydrase inhibitors: Inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid
Alessio Innocenti et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: Kinetic and X-ray crystallographic studies
Oezlen Guezel et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Carbonic anhydrase inhibitors: Interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV)
Alessio Innocenti et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
The alpha and beta classes carbonic Anhydrases from Helicobacter pylori as novel drug targets
Isao Nishimori et al.
CURRENT PHARMACEUTICAL DESIGN (2008)
Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
Claudiu T. Supuran
NATURE REVIEWS DRUG DISCOVERY (2008)
Saccharin inhibits carbonic anhydrases: Possible explanation for its unpleasant metallic aftertaste
Karen Koehler et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Carbonic anhydrase inhibitors: Clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue
Jean-Yves Winum et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
A novel class of carbonic anhydrase inhibitors: Glycoconjugate benzene sulfonamides prepared by click-tailing
Brendan L. Wilkinson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with L- and D-histidine and crystallographic analysis of their adducts with isoform II: Engineering proton-transfer processes within the active site of an enzyme
Claudia Temperini et al.
CHEMISTRY-A EUROPEAN JOURNAL (2006)
Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX
Vincenzo Alterio et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: Stereospecific recognition within the active site of an enzyme and its consequences for the drug design
Claudia Temperini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib
A Di Fiore et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II
V Menchise et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies
G De Simone et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: New pharmacological opportunities due to related binding site recognition
A Weber et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride
F Abbate et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX
F Abbate et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase
F Abbate et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH
E Svastová et al.
FEBS LETTERS (2004)
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a topically acting antiglaucoma sulfonamide
F Abbate et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide - Two heads are better than one?
A Casini et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the perfluorobenzoyl analogue of methazolamide. Implications for the drug design of fluorinated inhibitors
F Abbate et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2003)
Carbonic anhydrase inhibitors:: SAR and x-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with Isozymes I, II and IV
A Casini et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
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