Journal
EXPERIMENTAL EYE RESEARCH
Volume 193, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2020.107959
Keywords
Bacteria; Infection; Bacillus; Microbiology; Endophthalmitis; Inflammation
Categories
Funding
- National Institutes of Health [R01EY028810, R01EY024140, R01EY025947, R21EY028066]
- National Eye Institute Vision Core Grant [P30EY021725]
- Presbyterian Health Foundation Research Support Grant
- Presbyterian Health Foundation Equipment Grant Award
- Research to Prevent Blindness
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Bacillus cereus (B. cereus) endophthalmitis is a devastating intraocular infection primarily associated with post-traumatic injuries. The majority of these infections result in substantial vision loss, if not loss of the eye itself, within 12-48 h. Multifactorial mechanisms that lead to the innate intraocular inflammatory response during this disease include the combination of robust bacterial replication, migration of the organism throughout the eye, and toxin production by the organism. Therefore, the window of therapeutic intervention in B. cereus endophthalmitis is quite narrow compared to that of other pathogens which cause this disease. Understanding the interaction of bacterial and host factors is critical in understanding the disease and formulating more rational therapeutics for salvaging vision. In this review, we will discuss clinical and research findings related to B. cereus endophthalmitis in terms of the organism's virulence and inflammogenic potential, and strategies for improving of current therapeutic regimens for this blinding disease.
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