Journal
BIOTECHNOLOGY JOURNAL
Volume 10, Issue 5, Pages 715-U100Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/biot.201400392
Keywords
High-throughput screening; Modeling; Purification; Vaccine; VLP
Funding
- German Federal Ministry of Education and Research [0315640B]
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In recent years, the development of novel recombinant virus-like particles (VLPs) has been generating new perspectives for the prevention of untreated and arising infectious diseases. However, cost-reduction and acceleration of manufacturing processes for VLP-based vaccines or vectors are key challenges for the global health system. In particular, the design of rapid and cost-efficient purification processes is a critical bottleneck. In this review, we describe and evaluate new concepts, development strategies and unit operations for the downstream processing of VLPs. A special focus is placed on purity requirements and current trends, as well as chances and limitations of novel technologies. The discussed methods and case studies demonstrate the advances and remaining challenges in both rational process development and purification tools for large biomolecules. The potential of a new era of VLP-based products is highlighted by the progress of various VLPs in clinical phases.
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