Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 872, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2020.172954
Keywords
Morroniside; Acute myocardial infarction; Angiogenesis; Cardiac function; VEGF/VEGF receptor 2 signaling pathway
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Funding
- National Natural Science Foundation of China [81573633, 81503049]
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Angiogenesis is critical for re-establishing blood supply to the ischemic myocardium after acute myocardial infarction (AMI). This study aimed to investigate the effects of morroniside on angiogenesis after AMI and explored associated proangiogenic mechanisms. A rat model of AMI was established by ligation of the left anterior descending coronary artery followed by administration of three doses of morroniside. Immunofluorescence staining was performed to identify newly generated endothelial cells and arterioles. The protein expression levels associated with angiogenesis were examined by western blots. Echocardiography was used to examine cardiac function. Our data revealed that morroniside promoted angiogenesis and improved cardiac function in rats with AMI. The proangiogenic effect of morroniside might be mediated by the VEGFA/VEGF receptor 2 signaling pathway.
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