Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2020, Issue 22, Pages 3317-3319Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202000377
Keywords
Nitrogen heterocycles; Reduction; Electrochemistry; N ligands; Synthetic methods
Categories
Funding
- Russian Science Foundation [18-73-10156]
- Japanese Government
- Loughborough University
- Russian Science Foundation [18-73-10156] Funding Source: Russian Science Foundation
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Deoxygenation of heteroaromatic N-oxides is commonly accomplished using chemical or enzymatic methods. In this work, we report on an expedient protocol for electrochemical reduction of pyridine N-oxide derivatives under mild conditions. A diverse range of mono- and bis N-oxides were converted into the corresponding nitrogen bases in good yields. Importantly, the method is highly selective towards N-oxides and tolerates challenging halo and nitro substituents in the heteroaromatic ring.
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