Journal
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
Volume 40, Issue 3-4, Pages 770-780Publisher
KARGER
DOI: 10.1159/000453137
Keywords
Ligusticum Chuanxiong Hort; Myocardial ischemia, spectrum-effect relationship
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Funding
- National Natural Science Foundation Item: Study on screening of active anti-inflammatory components from the traditional Chinese herbs via the target on cell adhesion molecules [30472178]
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Background/Aims: To study the spectrum-effect relationship and effective components of Ligusticum Chuanxiong Hort. (LCH) on the protection of canine myocardial ischemia. Methods: Fingerprint spectrum of LCH extracts was developed using high performance liquid chromatography (HPLC), and a canine model of acute myocardial ischemia was established by ligating the coronary artery. Bivariate correlation analysis and multivariate regression analysis were used to correlate the pharmacodynamics of LCH extract and its common peaks in HPLC. Results: The bioactive components of LCH were ligustrazine, ferulic acid, cnidilide and ligustilide. Ligustrazine and ferulic acid could significantly reduce serum lactic acid in canine model of acute myocardial ischemia, while ligustilide could significantly reduce the elevation of serum free fatty acid. Conclusions: The spectrum-effect relationship study shows that the effective components of LCH are ligustrazine, ferulic acid, cnidilide and ligustilide, which have protective effect on myocardial ischemia. (C) 2016 The Author(s) Published by S. Karger AG, Basel
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