Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 50, Issue 10, Pages 1525-1536Publisher
WILEY
DOI: 10.1002/eji.201948497
Keywords
Activation; Dendritic cells; TLR3; Migration; Type I interferon
Categories
Funding
- Vetenskapsradet Young Investigator Award [2014-3595]
- Ragnar Soderberg Foundation Fellowship in Medicine
- Lundbeck Foundation Research Fellowship
- Ake Wiberg Foundation
- Carl Trygger Foundation
- Crafoord Foundation
- MARIE CURIE Fellowship as part of the EU
- Vetenskapsradet [521-2012-2637]
- Lundberg Foundation
Ask authors/readers for more resources
Initiation of adaptive immunity to particulate antigens in lymph nodes largely depends on their presentation by migratory dendritic cells (DCs). DC subsets differ in their capacity to induce specific types of immunity, allowing subset-specific DC-targeting to influence vaccination and therapy outcomes. Faithful drug design, however, requires exact understanding of subset-specific versus global activation mechanisms. cDC1, the subset of DCs that excel in supporting immunity toward viruses, intracellular bacteria, and tumors, express uniquely high levels of the pattern recognition receptor TLR3. Using various murine genetic models, we show here that both, the cDC1 and cDC2 subsets of cDCs are activated and migrate equally well in response to TLR3 stimulation in a cell extrinsic and TNF-alpha dependent manner, but that cDC1 show a unique requirement for type I interferon signaling. Our findings reveal common and differing pathways regulating DC subset migration, offering important insights for the design of DC-based vaccination and therapy approaches.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available