Journal
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
Volume 58, Issue 3, Pages 500-510Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ejcts/ezaa093
Keywords
Bioprinting; Revascularization; Transplantation; Regenerative medicine; Cardiac tissues; Stem cells
Funding
- Sir John Loewenthal Scholarship 2019 (University of Sydney)
- Le Gros Legacy Fund New Zealand [PhD012019]
- Heart Research Australia PhD Scholarship [2019-02]
- University of Sydney Kick-Start Grant
- University of Sydney Chancellor's Doctoral Incentive Programme Grant
- Sydney Medical School Foudation Cardiothoracic Surgery Research Grant
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Previous attempts in cardiac bioengineering have failed to provide tissues for cardiac regeneration. Recent advances in 3-dimensional bioprinting technology using prevascularized myocardial microtissues as 'bioink' have provided a promising way forward. This review guides the reader to understand why myocardial tissue engineering is difficult to achieve and how revascularization and contractile function could be restored in 3-dimensional bioprinted heart tissue using patient-derived stem cells.
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