Journal
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
Volume 39, Issue 6, Pages 2381-2397Publisher
KARGER
DOI: 10.1159/000452507
Keywords
miRs; Exosomes; Gene expression; Skeletal muscle; Endurance; Muscle strength; Leukocyte function; Heart
Categories
Funding
- Sao Paulo State Research Foundation (FAPESP)
- Coordination for the Improvement of Higher Level Personnel (CAPES)
- National Council for Scientific and Technological Development (CNPq)
- National Institute of Science and Technology in Obesity and Diabetes (INOD)
- Office for Post-Graduate and Research of the Cruzeiro do Sul University
- Office for Research of the University of Sao Paulo
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Gene expression control by microRNAs ( miRs) is an important mechanism for maintenance of cellular homeostasis in physiological and pathological conditions as well as in response to different stimuli including nutritional factors and exercise. MiRs are involved in regulation of several processes such as growth and development, fuel metabolism, insulin secretion, immune function, miocardium remodeling, cell proliferation, differenciation, survival, and death. These molecules have also been proposed to be potential biomarkers and/or therapeutical targets in obesity, type 2 diabetes mellitus, cardiovascular diseases, metabolic syndrome, and cancer. MiRs are released by most cells and potentially act on intercellular communication to borderer or distant cells. Various studies have been performed to elucidate the involvement of miRs in exercise-induced effects. The aims of this review are: 1) to bring up the main advances for the comprehension of the mechanisms of action of miRs; 2) to present the main results on miR involvement in physical exercise; 3) to discuss the physiological effects of miRs modified by exercise. The state of the art and the perspectives on miRs associated with physical exercise will be presented. Thus, this review is important for updating recent advances and driving further strategies and studies on the exercise-related miR research. (C) 2016 The Author(s) Published by S. Karger AG, Basel
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