Journal
CELLULAR MICROBIOLOGY
Volume 18, Issue 12, Pages 1739-1750Publisher
WILEY
DOI: 10.1111/cmi.12608
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Funding
- Singapore Immunology Network [07-009]
- Singapore's Agency for Science, Technology and Research (A*STAR)
- Yong Loo Lin School of Medicine, National University of Singapore (Singapore)
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The development of an effective malaria vaccine has remained elusive even until today. This is because of our incomplete understanding of the immune mechanisms that confer and/or correlate with protection. Human volunteers have been protected experimentally from a subsequent challenge by immunization with Plasmodium falciparum sporozoites under drug cover. Here, we demonstrate that sera from the protected individuals contain neutralizing antibodies against the pre-erythrocytic stage. To identify the antigen(s) recognized by these antibodies, a newly developed library of P. falciparum antigens was screened with the neutralizing sera. Antibodies from protected individuals recognized a broad antigenic repertoire of which three antigens, PfMAEBL, PfTRAP and PfSEA1 were recognized by most protected individuals. As a proof of principle, we demonstrated that anti-PfMAEBL antibodies block liver stage development in human hepatocytes. Thus, these antigens identified are promising targets for vaccine development against malaria.
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