Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 73, Issue 15, Pages 2829-2850Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-016-2130-4
Keywords
Adriamycin; ATM; ATR; Axin; c-Abl; BAX; Cancer therapy; Caspase 2; Chk1; Chk2; Doxorubicin; FOXO3; HIPK2; Hippo pathway; Ionizing radiation; Yap1; MLKL; p53; p53 Serine 46; p73; PML; PIDD; Pin1; PUMA; RIPK1; RIPK3; SUMO; XAF1
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Funding
- Cellular surveillance and damage control - Deutsche Forschungsgemeinschaft (DFG) [SFB 1036]
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Upon massive DNA damage cells fail to undergo productive DNA repair and trigger the cell death response. Resistance to cell death is linked to cellular transformation and carcinogenesis as well as radio- and chemoresistance, making the underlying signaling pathways a promising target for therapeutic intervention. Diverse DNA damage-induced cell death pathways are operative in mammalian cells and finally culminate in the induction of programmed cell death via activation of apoptosis or necroptosis. These signaling routes affect nuclear, mitochondria- and plasma membrane-associated key molecules to activate the apoptotic or necroptotic response. In this review, we highlight the main signaling pathways, molecular players and mechanisms guiding the DNA damage-induced cell death response.
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