Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 73, Issue 17, Pages 3311-3321Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-016-2229-7
Keywords
Stromal cells; Heterogeneity; Cell surface markers; PDGFR; CD146
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Funding
- Natural Science Foundation of China [31371404, 31571429]
- Natural Science Foundation of Guangdong [2015A030311041]
- Shenzhen Science and Technology Innovation Committee [JCYJ20140417115840279, GJHZ20150316160614842]
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Mesenchymal stem cells (MSC) are capable of differentiating into cells of multiple cell lineages and have potent paracrine effects. Due to their easy preparation and low immunogenicity, MSC have emerged as an extremely promising therapeutic agent in regenerative medicine for diverse diseases. However, MSC are heterogeneous with respect to phenotype and function in current isolation and cultivation regimes, which often lead to incomparable experimental results. In addition, there may be specific stem cell subpopulations with definite differentiation capacity toward certain lineages in addition to stem cells with multi-differentiation potential. Recent studies have identified several subsets of MSC which exhibit distinct features and biological activities, and enhanced therapeutic potentials for certain diseases. In this review, we give an overview of these subsets for their phenotypic, biological and functional properties.
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