Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 73, Issue 16, Pages 2999-3007Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-016-2210-5
Keywords
Radiotherapy; Cancer; Metastasis; Migration; Cytokine; Circulating tumor cells
Categories
Funding
- National Institutes of Health [P01 CA67166, R01 CA197136]
- California Breast Cancer Research Program [19IB-0106]
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It is well known that tumor cells migrate from the primary lesion to distant sites to form metastases and that these lesions limit patient outcome in a majority of cases. However, the extent to which radiation influences this process and to which migration in turn alters radiation response remains controversial. There are preclinical and clinical reports showing that focal radiotherapy can both increase the development of distant metastasis, as well as that it can induce the regression of established metastases through the abscopal effect. More recently, preclinical studies have suggested that radiation can attract migrating tumor cells and may, thereby, facilitate tumor recurrence. In this review, we summarize these phenomena and their potential mechanisms of action, and evaluate their significance for modern radiation therapy strategies.
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