Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 73, Issue 22, Pages 4265-4278Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-016-2294-y
Keywords
C. albicans; Morphogenesis; Virulence; Translational control; mRNA stability; Alternative transcript localization; Antifungal strategies
Categories
Funding
- National Institute of Allergy and Infectious Diseases [5R01AI083344, 1R21AI117299]
- Young Investigator Award from the Max and Minnie Tomerlin Voelcker Fund
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Candida albicans is a major human fungal pathogen responsible for both systemic and mucosal infections in a wide variety of immunocompromised individuals. Because the ability of C. albicans to undergo a reversible morphological transition from yeast to filaments is important for virulence, significant research efforts have focused on mechanisms that control this transition. While transcriptional and post-translational mechanisms have been well-studied, considerably less is known about the role of post-transcriptional mechanisms. However, in recent years several discoveries have begun to shed light on this important, but understudied, area. Here, I will review a variety of post-transcriptional mechanisms that have recently been shown to control C. albicans morphology, virulence and/or virulence-related processes, including those involving alternative transcript localization, mRNA stability and translation. I will also discuss the role that these mechanisms play in other pathogens as well as the potential they may hold to serve as targets for new antifungal strategies. Ultimately, gaining a better understanding of C. albicans post-transcriptional mechanisms will significantly improve our knowledge of how morphogenesis and virulence are controlled in fungal pathogens and open new avenues for the development of novel and more effective antifungals.
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