Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 73, Issue 11-12, Pages 2379-2386Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-016-2207-0
Keywords
Entosis; Entotic cell death; Cannibalism; Cell-in-cell; Engulfment; Phagocytosis; Autophagy; LAP; Cell competition; Aneuploidy
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Funding
- National Cancer Institute [R01CA154649]
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Multiple mechanisms have emerged where the engulfment of whole live cells, leading to the formation of what are called 'cell-in-cell' structures, induces cell death. Entosis is one such mechanism that drives cell-in-cell formation during carcinogenesis and development. Curiously, entotic cells participate actively in their own engulfment, by invading into their hosts, and are then killed non-cell-autonomously. Here we review the mechanisms of entosis and entotic cell death and the consequences of entosis on cell populations.
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