Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 73, Issue 11-12, Pages 2369-2378Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-016-2206-1
Keywords
Bacteria; Cell death; Regulated necrosis
Categories
Funding
- Institut Pasteur
- Institut National de la Sante et de la Recherche Medicale
- Agence Nationale de la Recherche
- LabEx IBEID
- Proantilis EU program
- European Research Council
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Necrosis has long been considered as a passive event resulting from a cell extrinsic stimulus, such as pathogen infection. Recent advances have refined this view and it is now well established that necrosis is tightly regulated at the cell level. Regulated necrosis can occur in the context of host-pathogen interactions, and can either participate in the control of infection or favor it. Here, we review the two main pathways implicated so far in bacteria-associated regulated necrosis: caspase 1-dependent pyroptosis and RIPK1/RIPK3-dependent necroptosis. We present how these pathways are modulated in the context of infection by a series of model bacterial pathogens.
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