Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 73, Issue 13, Pages 2411-2424Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-016-2166-5
Keywords
Cancer-related inflammation; Tumor-associated macrophages; Anti-tumor therapies; Macrophage targeting; Nanoparticles
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Myeloid cells infiltrating the tumor microenvironment, especially tumor-associated macrophages (TAMs), are essential providers of cancer-related inflammation, a condition known to accelerate tumor progression and limit the response to anti-tumor therapies. As a matter of fact, TAMs may have a dual role while interfering with cancer treatments, as they can either promote or impair their functionality. Here we review the connection between macrophages and anticancer therapies; moreover, we provide an overview of the different strategies to target or re-program TAMs for therapeutic purposes.
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