Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 74, Issue 4, Pages 697-713Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-016-2346-3
Keywords
Exosome; Microvesicle; Apoptotic body; Fibroblasts; Immune cells; Endothelial cells; Epithelial cells; Mesenchymal stem cells
Categories
Funding
- JSPS [15K21646, 15K10473]
- Council for Science
- Japan Agency for Medical Research and development, AMED
- Grants-in-Aid for Scientific Research [15K21646, 15K10473] Funding Source: KAKEN
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Intercellular communication plays an important role in cancer initiation and progression through secretory molecules, including growth factors and cytokines. Recent advances have revealed that small membrane vesicles, termed extracellular vesicles (EVs), served as a regulatory agent in the intercellular communication of cancer. EVs enable the transfer of functional molecules, including proteins, mRNA and microRNAs (miRNAs), into recipient cells. Cancer cells utilize EVs to dictate the unique phenotype of surrounding cells, thereby promoting cancer progression. Against such education by cancer cells, non-tumoral cells suppress cancer initiation and progression via EVs. Therefore, researchers consider EVs to be important cues to clarify the molecular mechanisms of cancer biology. Understanding the functions of EVs in cancer progression is an important aspect of cancer biology that has not been previously elucidated. In this review, we summarize experimental data that indicate the pivotal roles of EVs in cancer progression.
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