Journal
ENDOCRINE REVIEWS
Volume 41, Issue 4, Pages -Publisher
ENDOCRINE SOC
DOI: 10.1210/endrev/bnaa009
Keywords
DNA damage response; DNA repair; growth hormone; IGF1; alpha MSH; gonadotropins
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Funding
- National Institutes of Health [DK113998]
- Doris Factor Molecular Endocrinology Laboratory at Cedars-Sinai
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DNA damage response (DDR) and DNA repair pathways determine neoplastic cell transformation and therapeutic responses, as well as the aging process. Altered DDR functioning results in accumulation of unrepaired DNA damage, increased frequency of tumorigenic mutations, and premature aging. Recent evidence suggests that polypeptide hormones play a role in modulating DDR and DNA damage repair, while DNA damage accumulation may also affect hormonal status. We review the available reports elucidating involvement of insulin-like growth factor 1 (IGF1), growth hormone (GH), alpha-melanocyte stimulating hormone (alpha MSH), and gonadotropin-releasing hormone (GnRH)/gonadotropins in DDR and DNA repair as well as the current understanding of pathways enabling these actions. We discuss effects of DNA damage pathway mutations, including Fanconi anemia, on endocrine function and consider mechanisms underlying these phenotypes.
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