Related references
Note: Only part of the references are listed.Targeting the Unfolded Protein Response in Hormone-Regulated Cancers
Yang Jin et al.
TRENDS IN CANCER (2020)
p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
Alessandro Carugo et al.
CANCER CELL (2019)
A positive role of c-Myc in regulating androgen receptor and its splice variants in prostate cancer
Shanshan Bai et al.
ONCOGENE (2019)
IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
Xia Sheng et al.
NATURE COMMUNICATIONS (2019)
A negative feedback loop between XBP1 and Fbw7 regulates cancer development
Unbin Chae et al.
ONCOGENESIS (2019)
The metastasis suppressor, NDRG1, differentially modulates the endoplasmic reticulum stress response
A. M. Merlot et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)
Endoplasmic reticulum proteostasis control and gastric cancer
Yu Wang et al.
CANCER LETTERS (2019)
Metabolic Reprogramming by MYCN Confers Dependence on the Serine-Glycine-One-Carbon Biosynthetic Pathway
Yingfeng Xia et al.
CANCER RESEARCH (2019)
The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc
Han Dong et al.
NATURE IMMUNOLOGY (2019)
ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression
Feven Tameire et al.
NATURE CELL BIOLOGY (2019)
Pharmacological targeting of the unfolded protein response for disease intervention
Claudio Hetz et al.
NATURE CHEMICAL BIOLOGY (2019)
Mutant p53 improves cancer cells' resistance to endoplasmic reticulum stress by sustaining activation of the UPR regulator ATF6
Dania Sicari et al.
ONCOGENE (2019)
Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer Nora
Nora Pallmann et al.
ONCOGENE (2019)
The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance
Emma Madden et al.
BIOLOGY OF THE CELL (2019)
The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum
G. Elif Karagoz et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2019)
C-myc/miR-150/EPG5 axis mediated dysfunction of autophagy promotes development of non-small cell lung cancer
Hui Li et al.
THERANOSTICS (2019)
Dual IRE1 RNase functions dictate glioblastoma development
Stephanie Lhomond et al.
EMBO MOLECULAR MEDICINE (2018)
Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer
Na Zhao et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers
Hong Xie et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response
L. N. Huiting et al.
LEUKEMIA (2018)
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule
Jordan C. Tsai et al.
SCIENCE (2018)
Development of a stress response therapy targeting aggressive prostate cancer
Hao G. Nguyen et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
The protective autophagy activated by GANT-61 in MYCN amplified neuroblastoma cells is mediated by PERK
Jing Wang et al.
Oncotarget (2018)
MYC-related microRNAs signatures in non-Hodgkin B-cell lymphomas and their relationships with core cellular pathways
Giorgio Malpeli et al.
Oncotarget (2018)
ER stress-related ATF6 upregulates CIP2A and contributes to poor prognosis of colon cancer
Chun-Yu Liu et al.
MOLECULAR ONCOLOGY (2018)
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy
Susan E. Logue et al.
NATURE COMMUNICATIONS (2018)
IRE1 alpha-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity
Minkyung Song et al.
NATURE (2018)
Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer
Giannicola Genovese et al.
NATURE (2017)
Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells
Inge M. N. Wortel et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)
Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer
Svitlana Tyekucheva et al.
NATURE COMMUNICATIONS (2017)
Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis
Ming Yue et al.
CELL REPORTS (2017)
MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation
Kyung-Min Lee et al.
CELL METABOLISM (2017)
Targeting autophagy in cancer
Jean M. Mulcahy Levy et al.
NATURE REVIEWS CANCER (2017)
Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer
Juan R. Cubillos-Ruiz et al.
CELL (2017)
The endoplasmic reticulum: structure, function and response to cellular signaling
Dianne S. Schwarz et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2016)
Therapeutic potential of targeting IRES-dependent c-myc translation in multiple myeloma cells during ER stress
Y. Shi et al.
ONCOGENE (2016)
The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma
David Y. A. Dadey et al.
ONCOTARGET (2016)
Critical role of XBP1 in cancer signalling is regulated by PIN1
Unbin Chae et al.
BIOCHEMICAL JOURNAL (2016)
N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer
Etienne Dardenne et al.
CANCER CELL (2016)
The integrated stress response
Karolina Pakos-Zebrucka et al.
EMBO REPORTS (2016)
Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer
Dong-Wook Kim et al.
GENES & DEVELOPMENT (2016)
Protein misfolding in the endoplasmic reticulum as a conduit to human disease
Miao Wang et al.
NATURE (2016)
Prostate cancer and the unfolded protein response
Margrethe Storm et al.
ONCOTARGET (2016)
Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells
Mengling Liu et al.
CELL REPORTS (2016)
Endoplasmic Reticulum Stress and the Hallmarks of Cancer
Hery Urra et al.
TRENDS IN CANCER (2016)
Splicing and Dicing MYC-Mediated Synthetic Lethality
Zachary E. Stine et al.
CANCER CELL (2015)
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis
Juan R. Cubillos-Ruiz et al.
CELL (2015)
Divergent androgen regulation of unfolded protein response pathways drives prostate cancer
Xia Sheng et al.
EMBO MOLECULAR MEDICINE (2015)
Targeting the adaptive molecular landscape of castration-resistant prostate cancer
Alexander W. Wyatt et al.
EMBO MOLECULAR MEDICINE (2015)
Proteostasis control by the unfolded protein response
Claudio Hetz et al.
NATURE CELL BIOLOGY (2015)
ER proteostasis addiction in cancer biology: Novel concepts
Estefanie Dufey et al.
SEMINARS IN CANCER BIOLOGY (2015)
Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy
Feven Tameire et al.
SEMINARS IN CANCER BIOLOGY (2015)
Taming of the beast: shaping Myc-dependent amplification
Elmar Wolf et al.
TRENDS IN CELL BIOLOGY (2015)
Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis
Eric Chevet et al.
CANCER DISCOVERY (2015)
MYC: connecting selective transcriptional control to global RNA production
Theresia R. Kress et al.
NATURE REVIEWS CANCER (2015)
Endoplasmic Reticulum Stress in Malignancy
Hanna J. Clarke et al.
CANCER CELL (2014)
Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway
Zhao V. Wang et al.
CELL (2014)
The Metastasis Suppressor, N-myc Downstream-regulated Gene 1 (NDRG1), Inhibits Stress-induced Autophagy in Cancer Cells
Sumit Sahni et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
ER-associated degradation: Protein quality control and beyond
Annamaria Ruggiano et al.
JOURNAL OF CELL BIOLOGY (2014)
MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer
Ayesha N. Shajahan-Haq et al.
MOLECULAR CANCER (2014)
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
Xi Chen et al.
NATURE (2014)
Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors
Mario Sanches et al.
NATURE COMMUNICATIONS (2014)
An Overview of MYC and Its Interactome
Maralice Conacci-Sorrell et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2014)
Physiological roles of regulated Ire1 dependent decay
Dina S. Coelho et al.
FRONTIERS IN GENETICS (2014)
The impact of the endoplasmic reticulum protein-folding environment on cancer development
Miao Wang et al.
NATURE REVIEWS CANCER (2014)
Role of Nrf2 in Oxidative Stress and Toxicity
Qiang Ma
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013 (2013)
Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity
Charity Atkins et al.
CANCER RESEARCH (2013)
Identification of a novel BET bromodomain inhibitor-sensitive, gene regulatory circuit that controls Rituximab response and tumour growth in aggressive lymphoid cancers
Anouk Emadali et al.
EMBO MOLECULAR MEDICINE (2013)
Mammalian Target of Rapamycin Complex 1 (mTORC1) Enhances Bortezomib-induced Death in Tuberous Sclerosis Complex (TSC)-null Cells by a c-MYC-dependent Induction of the Unfolded Protein Response
Justin T. Babcock et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Targeting the unfolded protein response in disease
Claudio Hetz et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development
Jeffrey M. Axten et al.
ACS MEDICINAL CHEMISTRY LETTERS (2013)
SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease
Jiyung Shin et al.
CELL REPORTS (2013)
Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments
Matthew D. Shoulders et al.
CELL REPORTS (2013)
The Role of MIZ-1 in MYC-Dependent Tumorigenesis
Katrin E. Wiese et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2013)
Myc-Driven Overgrowth Requires Unfolded Protein Response-Mediated Induction of Autophagy and Antioxidant Responses in Drosophila melanogaster
Peter Nagy et al.
PLOS GENETICS (2013)
Serine, glycine and one-carbon units: cancer metabolism in full circle
Jason W. Locasale
NATURE REVIEWS CANCER (2013)
The Cdc48 machine in endoplasmic reticulum associated protein degradation
Dieter H. Wolf et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)
ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation
Guoliang Qing et al.
CANCER CELL (2012)
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth
Lori S. Hart et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland
Xiaoyan Wang et al.
CANCER RESEARCH (2011)
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
Peter Walter et al.
SCIENCE (2011)
c-Myc Regulates Transcriptional Pause Release
Peter B. Rahl et al.
CELL (2010)
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
Goekhan S. Hotamisligil
CELL (2010)
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5
Kasper M. A. Rouschop et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
The landscape of somatic copy-number alteration across human cancers
Rameen Beroukhim et al.
NATURE (2010)
Targeting c-Myc as a novel approach for hepatocellular carcinoma
Che-Pin Lin et al.
WORLD JOURNAL OF HEPATOLOGY (2010)
MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy
Kerry J. Savage et al.
BLOOD (2009)
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells
Julie Hollien et al.
JOURNAL OF CELL BIOLOGY (2009)
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
Inki Kim et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
JNK signaling in apoptosis
D. N. Dhanasekaran et al.
ONCOGENE (2008)
ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo
Denis M. Schewe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Etiology-dependent molecular mechanisms in human hepatocarcinogenesis
Christof Schlaeger et al.
HEPATOLOGY (2008)
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6α and XBP1
Keisuke Yamamoto et al.
DEVELOPMENTAL CELL (2007)
Childhood tumors of the nervous system as disorders of normal development
Matthew R. Grimmer et al.
CURRENT OPINION IN PEDIATRICS (2006)
Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway
Malte Buchholz et al.
EMBO JOURNAL (2006)
Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation
K Tamura et al.
EMBO JOURNAL (2005)
Translational control in stress and apoptosis
M Holcik et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism
D Barsyte-Lovejoy et al.
ONCOGENE (2004)
Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation
J Averous et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
SB Cullinan et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Genomic targets of the human c-Myc protein
PC Fernandez et al.
GENES & DEVELOPMENT (2003)
Essential role of calcineurin in response to endoplasmic reticulum stress
M Bonilla et al.
EMBO JOURNAL (2002)
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
M Calfon et al.
NATURE (2002)
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
H Yoshida et al.
CELL (2001)
Regulated translation initiation controls stress-induced gene expression in mammalian cells
HP Harding et al.
MOLECULAR CELL (2000)
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum
CY Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
ATF6 as a transcription activator of the endoplasmic reticulum stress element: Thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1
MQ Li et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Perk is essential for translational regulation and cell survival during the unfolded protein response
HP Harding et al.
MOLECULAR CELL (2000)
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
F Urano et al.
SCIENCE (2000)
Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma
YP Shou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)