Journal
CELLS TISSUES ORGANS
Volume 202, Issue 1-2, Pages 102-115Publisher
KARGER
DOI: 10.1159/000446647
Keywords
Nanoparticle; Drug delivery; Spinal cord injury; Chondroitinase ABC; Poly-L-lactic acid
Funding
- NSF [NSF CAREER 1105125]
- NIH [R01 NS092754]
- New York State Department of Health Spinal Cord Injury Research Fund [C022046, C020931]
- SUNY Health Science Foundation
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Nanoparticles are increasingly being studied within experimental models of spinal cord injury (SCI). They are used to image cells and tissue, move cells to specific regions of the spinal cord, and deliver therapeutic agents locally. The focus of this article is to provide a brief overview of the different types of nanoparticles being studied for spinal cord applications and present data showing the capability of nanoparticles to deliver the chondroitinase ABC (chABC) enzyme locally following acute SCI in rats. Nanoparticles releasing chABC helped promote axonal regeneration following injury, and the nanoparticles also protected the enzyme from rapid degradation. In summary, nanoparticles are viable materials for diagnostic or therapeutic applications within experimental models of SCI and have potential for future clinical use. (C) 2016 S. Karger AG, Basel
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