Journal
DRUG DISCOVERY TODAY
Volume 25, Issue 6, Pages 1034-1042Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2020.03.006
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Funding
- Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Sciences (TUOMS)
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Computational epitope-based vaccine design is the cornerstone of vaccine development. Owing to the selection of proper compositions [antigens (Ags), epitopes, peptide linkers, and intramolecular adjuvants], epitope-based vaccines are considered a cost- and time-effective approach resulting in the development of vaccines with maximal therapeutic efficacy and minimal adverse reactions. In this review, we provide insights into in silico epitope-based vaccine design and highlight vaccinology procedures used for the development of the next-generation vaccines with high effectiveness.
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