Journal
Cell Stem Cell
Volume 19, Issue 6, Pages 686-689Publisher
CELL PRESS
DOI: 10.1016/j.stem.2016.11.009
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Funding
- NHLBI NIH HHS [R01 HL118185, K99 HL127181, R00 HL127181, R01 HL116756] Funding Source: Medline
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Feedback signals from daughter cells to stem cells are well studied and known to provide important feedback cues. Emerging evidence shows that stem cells also send feedforward signals to their progeny. Complex circuits involving both negative and positive feedback and feedforward signals likely contribute to robust tissue maintenance and regeneration.
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