Journal
CELL STEM CELL
Volume 18, Issue 3, Pages 309-321Publisher
CELL PRESS
DOI: 10.1016/j.stem.2016.02.011
Keywords
-
Categories
Funding
- European Research Council (STEMCARDIOVASC) [ERCAdG 323182]
- European Community's Seventh Framework Programme [602423, ZonMw-MKMD-40-42600-98-036]
Ask authors/readers for more resources
Defined genetic models based on human pluripotent stem cells have opened new avenues for understanding disease mechanisms and drug screening. Many of these models assume cell-autonomous mechanisms of disease but it is possible that disease phenotypes or drug responses will only be evident if all cellular and extracellular components of a tissue are present and functionally mature. To derive optimal benefit from such models, complex multicellular structures with vascular components that mimic tissue niches will thus likely be necessary. Here we consider emerging research creating human tissue mimics and provide some recommendations for moving the field forward.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available