Journal
CELL STEM CELL
Volume 19, Issue 5, Pages 573-586Publisher
CELL PRESS
DOI: 10.1016/j.stem.2016.10.015
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Funding
- NIH-NINDS [NS076352, NS086604]
- NIH-NIMH [MH099587, MH100031]
- Bleser Family Foundation
- Busta Foundation
- Dr. Ralph & Marian Falk Medical Research Trust [UW2020]
- NICHD [HD076892, U54 HD090256]
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Human pluripotent stem cells (hPSCs) provide a model to study early neural development, model pathological processes, and develop therapeutics. The generation of functionally specialized neural subtypes from hPSCs relies on fundamental developmental principles learned from animal studies. Manipulation of these principles enables production of highly enriched neural types with functional attributes that resemble those in the brain. Further development to promote faster maturation or aging as well as circuit integration will help realize the potential of hPSC-derived neural cells in disease modeling and cell therapy.
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