Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 26, Issue 34, Pages 4277-4284Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612826666200513112607
Keywords
Inflammation; gingivitis; herbal medicine; curcumin; periodontitis; herbal mouthwash
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Periodontal disease is one of the most common causes of tooth loss among adults. Research shows that inflammation is one of the crucial components in the initiation and progression of periodontitis. Various herbal medicines have recently been receiving attention for the management of periodontitis owing to their general safety and efficacy. Curcumin, a bioactive polyphenol extracted from Curcuma longa, has been shown to possess antioxidant, antimicrobial, anti-inflammatory and analgesic properties. Several studies have assessed the efficacy of curcumin against periodontal diseases. These studies have shown equivalent or even higher efficacy of curcumin compared to the commonly used medications for the management of periodontitis such as chlorhexidine. Herein, we review the experimental and clinical findings on the anti-periodontitis effects of curcumin and the pharmacological mechanisms underlying these effects.
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