Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 26, Issue 22, Pages 2661-2667Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612826666200317131940
Keywords
Anemia; aplastic; porcine anti-human lymphocyte globulin; immunosuppressive; treatment; hematopoietic
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Funding
- National Natural Science Foundation of China [81170472]
- Key Technology Research and Development Program of Tianjin [18ZXDBSY00140]
- Application Bases and Advanced Technology Research Program of Tianjin [14JCYBJC27200, 09JCYBJC11200]
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Aplastic anemia (AA) is a bone marrow failure syndrome characterized by pancytopenia. Decreased numbers of hematopoietic stem cells and impaired bone marrow microenvironment caused by abnormal immune function describe the major pathogenesis of AA. Hematopoietic stem cell transplantation and immunesuppressive therapy are the first-line treatments for AA. Porcine anti-lymphocyte globulin (p-ALG) is a new product developed in China. Several studies have shown that p-ALG exhibited good therapeutic effects in AA.
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