Journal
CURRENT ORGANIC SYNTHESIS
Volume 17, Issue 4, Pages 252-270Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570179417666200325124712
Keywords
Phthalimide; thalidomide; medicinal chemistry; anti-tumor; anti-inflammatory; antimicrobial
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Funding
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brasil)
- FACEPE (Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco)
- INCT_if (Instituto Nacional de Ciencia e Tecnologia para Inovacao Farmaceutica)
- CAPES
- CAIS/ISG (Centro Avancado para Inovcoes em Saude)
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Phthalimide derivatives have been presenting several promising biological activities in the literature, such as anti-inflammatory, analgesic, antitumor, antimicrobial and anticonvulsant. The most well-known and studied phthalimide derivative (isoindoline-1,3-dione) is thalidomide: this compound initially presented important sedative effects, but it is now known that thalidomide has effectiveness against a wide variety of diseases, including inflammation and cancer. This review approaches some of the recent and efficient chemical synthesis pathways to obtain phthalimide analogues and also presents a summary of the main biological activities of these derivatives found in the literature. Therefore, this review describes the chemical and therapeutic aspects of phthalimide derivatives.
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