Journal
CELL RESEARCH
Volume 26, Issue 5, Pages 511-512Publisher
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/cr.2016.19
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- NCI NIH HHS [P30 CA008748] Funding Source: Medline
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DROSHA and its partner DGCR8 form a heterotrimeric complex named Microprocessor, which is essential for microRNA biogenesis. A recent study by Kwon et al. in Cell reveals the structure of a DROSHA construct in complex with the C-terminal region of DGCR8, thereby unveiling the topology and interactions between components of the Microprocessor and insights into its 'ruler'-based cleavage activity and function.
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