Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 55, Issue -, Pages 145-150Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2020.01.011
Keywords
zinc proteome; organelle zinc homeostasis; zinc storage; metalation; zinc deficiency
Categories
Funding
- National Institutes of Health [R01 GM105695]
Ask authors/readers for more resources
It is estimated that up to 10% of proteins in eukaryotes require zinc for their function. Although the majority of these proteins are located in the nucleus and cytosol, a small subset is secreted from cells or is located within an intracellular compartment. As many of these compartmentalized metalloproteins fold to their native state and bind their zinc cofactor inside an organelle, cells require mechanisms to maintain supply of zinc to these compartments even under conditions of zinc deficiency. At the same time, intracellular compartments can also be the site for storing zinc ions, which then can be mobilized when needed. In this review, we highlight insight that has been obtained from yeast models about how zinc homeostasis is maintained in the secretory pathway and vacuole.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available