Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 55, Issue -, Pages 103-110Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2019.12.007
Keywords
Gold complexes; Catalysis; Cross-coupling reactions; Bio-orthogonal transformations; Therapy
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Funding
- EPSRC [EP/L016443/1]
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One of the challenges of modern inorganic chemistry is translating the potential of metal catalysts to living systems to achieve controlled non-natural transformations. This field poses numerous issues associated with the metal compounds biocompatibility, stability, and reactivity in complex aqueous environment. Moreover, it should be noted that although referring to 'metal catalysis', turnover has not yet been fully demonstrated in most of the examples within living systems. Nevertheless, transition metal catalysts offer an opportunity of modulating bioprocesses through reactions that are complementary to enzymes. In this context, gold complexes, both coordination and organometallic, have emerged as promising tools for bio-orthogonal transformations, endowed with excellent reactivity and selectivity, compatibility within aqueous reaction medium, fast kinetics of ligand exchange reactions, and mild reaction conditions. Thus, a number of examples of gold-templated reactions in a biologically relevant context will be presented and discussed here in relation to their potential applications in biological and medicinal chemistry.
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