Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 62, Issue -, Pages 153-159Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2019.09.014
Keywords
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Funding
- German Federal Ministry of Food and Agriculture (BMEL), through the Specialist agency renewable raw materials e. V. (FNR) [FKZ 22030515]
- Ministry of Culture and Science [313/323-400-002 13]
- Danish Strategic Research Program [11-116803]
- Fundacao Ciencia e Tecnologia [ERA-IB-2-6/0003/2014, UID/BIO/04565/2013, UID/BIO/04565/2019]
- Programa Operacional Regional de Lisboa 2020 [007317]
- Austrian Federal Ministry for Digital and Economic Affairs (bmwd)
- Federal Ministry for Transport, Innovation and Technology (bmvit)
- Styrian Business Promotion Agency SFG
- Standortagentur Tirol, Government of Lower Austria
- ZIT -Technology Agency of the City of Vienna through the COMET
- Fundação para a Ciência e a Tecnologia [ERA-IB-2-6/0003/2014, UID/BIO/04565/2019] Funding Source: FCT
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Some of the oldest and most established industrial biotechnology processes involve the fungal production of organic acids. In these fungi, the transport of metabolites between cellular compartments, and their secretion, is a major factor. In this review we exemplify the importance of both mitochondrial and plasma membrane transporters in the case of itaconic acid production in two very different fungal systems, Aspergillus and Ustilago. Homologous and heterologous overexpression of both types of transporters, and biochemical analysis of mitochondrial transporter function, show that these two fungi produce the same compound through very different pathways. The way these fungi respond to itaconate stress, especially at low pH, also differs, although this is still an open field which clearly needs additional research.
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