Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 62, Issue -, Pages 29-37Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.copbio.2019.08.004
Keywords
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Funding
- Biology and Biotechnology Research Council (BBSRC) [BB/M009769/1]
- European Union [633962]
- Royal Society
- Newton Fund (Newton Advanced Fellowship) [NA160328]
- BBSRC [BB/M009769/1] Funding Source: UKRI
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Bacterial cells have a limited number of resources that can be allocated for gene expression. The intracellular competition for these resources has an impact on the cell physiology. Bacteria have evolved mechanisms to optimize resource allocation in a variety of scenarios, showing a trade-off between the resources used to maximise growth (e.g. ribosome synthesis) and the rest of cellular functions. Limitations in gene expression also play a role in generating phenotypic diversity, which is advantageous in fluctuating environments, at the expenses of decreasing growth rates. Our current understanding of these trade-offs can be exploited for biotechnological applications benefiting from the selective manipulation of the allocation of resources.
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