Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 62, Issue -, Pages 65-71Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2019.09.004
Keywords
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Funding
- China Scholarship Council
- RPI Biocatalysis and Metabolic Engineering Constellation Fund
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The microbial production of natural products has been traditionally accomplished in a single organism engineered to accommodate target biosynthetic pathways. Often times, such approaches result in large metabolic burdens as key cofactors, precursor metabolites and energy are channeled to pathways of structurally complex chemicals. Recently, modular co-culture engineering has emerged as a new approach to efficiently conduct heterologous biosynthesis and greatly enhance the production of natural products. This review highlights recent advances that leverage Escherichia coli-based modular co-culture engineering for making natural products. Potential future perspectives for studies in this promising field are addressed as well.
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