Journal
CURRENT MEDICINAL CHEMISTRY
Volume 28, Issue 9, Pages 1757-1774Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867327666200427095830
Keywords
Matrix metalloproteases; acute coronary syndromes; vascular smooth muscle cells; polymorphism; atherosclerosis; Interlukin-18; therapeutic
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Atherosclerosis is a chronic inflammatory disorder of the cardiovascular system and IL-18 is a novel proinflammatory cytokine involved in its pathogenesis. Research on the role of IL-18 in AS could lead to novel prognostic and therapeutic approaches.
Atherosclerosis (AS), as a chronic inflammatory disorder of the cardiovascular system, is one of the leading causes of ischemic heart disease, stroke and peripheral vascular disease. There is growing evidence on the role of innate and adaptive immunity in the pathogenesis of atherosclerosis. Interleukin-18 is one of the novel proinflammatory cytokines involved in atherogenesis, atherosclerotic plaque instability and plaque rupture. In this review, we overview the findings of preclinical and clinical studies about the role and mechanism of action of IL-18 in the pathogenesis of AS, which could offer novel prognostic and therapeutic approaches.
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