Journal
CURRENT BIOLOGY
Volume 30, Issue 9, Pages 1589-+Publisher
CELL PRESS
DOI: 10.1016/j.cub.2020.02.004
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Funding
- ERC (EU
- NEURO-PATTERNS)
- NIH (USA) [U01 NS090576, U19 NS107464]
- Flag-Era JTC (EU
- SLOW-DYN) [FP7-602531]
- Marie Sklodowska-Curie program (EU) [699829]
- Marie Curie Actions (MSCA) [699829] Funding Source: Marie Curie Actions (MSCA)
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The timing of stimulus-evoked spikes encodes information about sensory stimuli. Here we studied the neural circuits controlling this process in the mouse primary somatosensory cortex. We found that brief optogenetic activation of layer V pyramidal cells just after whisker deflection modulated the membrane potential of neurons and interrupted their long-latency whisker responses, increasing their accuracy in encoding whisker deflection time. In contrast, optogenetic inhibition of layer V during either passive whisker deflection or active whisking decreased accuracy in encoding stimulus or touch time, respectively. Suppression of layer V pyramidal cells increased reaction times in a texture discrimination task. Moreover, two-color optogenetic experiments revealed that cortical inhibition was efficiently recruited by layer V stimulation and that it mainly involved activation of parvalbumin-positive rather than somatostatin-positive interneurons. Layer V thus performs behaviorally relevant temporal sharpening of sensory responses through circuit-specific recruitment of cortical inhibition.
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