Journal
CELL METABOLISM
Volume 23, Issue 6, Pages 1034-1047Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2016.05.007
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Funding
- NIA NIH HHS [R01 AG010026] Funding Source: Medline
- NIDDK NIH HHS [P30 DK020541, R01 DK071771, P30 DK079626, P30 DK020572] Funding Source: Medline
- Novo Nordisk Fonden [NNF14OC0011493] Funding Source: researchfish
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Primary aging is the progressive and inevitable process of bodily deterioration during adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and reduced muscle mass. Secondary aging refers to additional deleterious structural and functional age-related changes caused by diseases and lifestyle factors. Secondary aging can exacerbate deficits in mitochondrial function and muscle mass, concomitant with the development of skeletal muscle insulin resistance. Exercise opposes deleterious effects of secondary aging by preventing the decline in mitochondrial respiration, mitigating aging-related loss of muscle mass and enhancing insulin sensitivity. This review focuses on mechanisms by which exercise promotes healthy aging'' by inducing modifications in skeletal muscle.
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