A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

Ischemia-reperfusion (IR) injury occurs when blood supply to an organ is disrupted-ischemia-and then restored-reperfusion-leading to a burst of reactive oxygen species (ROS) from mitochondria. It has been tacitly assumed that ROS production during IR is a non-specific consequence of oxygen interacting with dysfunctional mitochondria upon reperfusion. Recently, this view has changed, suggesting that ROS production during IR occurs by a defined mechanism. Here we survey the metabolic factors underlying IR injury and propose a unifying mechanism for its causes that makes sense of the huge amount of disparate data in this area and provides testable hypotheses and new directions for therapies.