Journal
CELL METABOLISM
Volume 23, Issue 6, Pages 1200-1206Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2016.04.029
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Funding
- Institute for Translational Sciences at the University of Texas Medical Branch
- National Center for Advancing Translational Sciences, National Institutes of Health [UL1TR000071]
- American Diabetes Association [1-14-TS-35]
- Shriners Hospitals for Children [84090, 85310]
- John Sealy Memorial Endowment Fund for Biomedical Research [66992]
- Claude Pepper Older Americans Independence Center [P30 AG024832]
- Sealy Center on Aging
- NIH [DK97441]
- Onassis Foundation
- Canadian Institute of Health Research
- National Institute of Disability and Rehabilitation Research Postdoctoral Training Grant [H133P110012]
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Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose metabolism in humans. However, the physiological significance of human BAT in lipid metabolism remains unknown. We studied 16 overweight/obese men during prolonged, non-shivering cold and thermoneutral conditions using stable isotopic tracer methodologies in conjunction with hyperinsulinemic-euglycemic clamps and BAT and white adipose tissue (WAT) biopsies. BAT volume was significantly associated with increased whole-body lipolysis, triglyceride-free fatty acid (FFA) cycling, FFA oxidation, and adipose tissue insulin sensitivity. Functional analysis of BAT and WAT demonstrated the greater thermogenic capacity of BAT compared to WAT, while molecular analysis revealed a cold-induced upregulation of genes involved in lipid metabolism only in BAT. The accelerated mobilization and oxidation of lipids upon BAT activation supports a putative role for BAT in the regulation of lipid metabolism in humans.
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