Absorption, metabolism, and bioactivity of vitexin: recent advances in understanding the efficacy of an important nutraceutical

vitexin, an apigenin-8-C-glucoside, is widely present in numerous edible and medicinal plants. vitexin possesses a variety of bioactive properties, including antioxidation, anti-inflammation, anti-cancer, neuron-protection, and cardio-protection. Other beneficial health effects, such as fat reduction, glucose metabolism, and hepatoprotection, have also been reported in recent studies. This review briefly discusses the absorption and metabolism of vitexin, as well as its influence on gut microbiota. Recent advances in understanding the pharmacological and biological effects of vitexin are then reviewed. Improved knowledge of the absorption, metabolism, bioactivity, and molecular targets of vitexin is crucial for the better utilization of this emerging nutraceutical as a chemopreventive and chemotherapeutic agent.

Automated summary

Vitexin, an apigenin-8-C-glucoside found in many edible and medicinal plants, has various bioactive properties such as antioxidation, anti-inflammation, anti-cancer, neuron-protection, and cardio-protection. Recent studies have also reported beneficial health effects including fat reduction, glucose metabolism, and hepatoprotection. Understanding the absorption, metabolism, bioactivity, and molecular targets of vitexin is important for its utilization as a chemopreventive and chemotherapeutic agent.