Journal
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Volume 61, Issue 8, Pages 1404-1414Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2020.1759025
Keywords
Biological activities; biomass; biosynthesis; health benefits; lignanamides
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Funding
- University of Melbourne Research Scholarship, and Industry Research Sponsorship by Target Makmur Sentosa, Indonesia
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Lignanamides are natural plant secondary metabolites with powerful anti-inflammatory, antioxidant, anti-cancer, and anti-hyperlipidemic capacities, attracting researchers' interest for their potential in protecting against human chronic diseases. Although details in molecular regulation of the coupling process remain unclear, the general biosynthesis pathway for lignanamides is comprehensively summarized, calling for additional clinical studies to prove their health benefits.
Lignanamides are natural plant secondary metabolites derived from oxidative coupling mechanism with hydroxycinnamic acid amides as intermediates. These compounds display powerful anti-inflammatory, antioxidant, anti-cancer and anti-hyperlipidemic capacities in vitro, cell culture and in vivo studies. With strong potential to be utilized as protective agents against human chronic diseases, these compounds have attracted the interest of researchers. This review aims to discuss current understanding on the sources, classification, biosynthesis of lignanamides in plants, and importantly their biological activity and potential health benefits. The general biosynthesis pathway for lignanamides is comprehensively summarized, though some details in molecular regulation of the coupling process have yet to be elucidated. Lignanamides deserves additional clinical studies involving animal and human subjects, to prove its health benefits.
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