Journal
CELL METABOLISM
Volume 23, Issue 6, Pages 1060-1065Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2016.05.011
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Funding
- NIA NIH HHS [R24 AG044396, R01 AG046949, P30 AG021332, P30 AG038072, P01 AG027734, R37 AG018381, P01 AG021654] Funding Source: Medline
- NIDDK NIH HHS [U01 DK048349] Funding Source: Medline
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Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.
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