Journal
CELL METABOLISM
Volume 24, Issue 3, Pages 379-387Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2016.08.013
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Funding
- Gruber Science Fellowship
- HHMI
- Blavatnik Family Foundation
- Else Kroner Fresenius Foundation
- NIH [AI046688, AI089771, CA157461]
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Itaconate is a newly discovered mammalian metabolite bearing significant implications for our understanding of cellular immunometabolism and antimicrobial defense. Here, we explore recent findings regarding the role of itaconate in the innate immune response and highlight the emerging principle that metabolites can have distinct immunological functions independent of bioenergetics.
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