Journal
CELL HOST & MICROBE
Volume 19, Issue 4, Pages 550-559Publisher
CELL PRESS
DOI: 10.1016/j.chom.2016.02.021
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Funding
- PIDS-St. Jude Research Hospital Fellowship Program in Basic Research
- K12 Child Health Research Center grant through BCH
- BBSRC [BB/K004468/1, BB/J014427/1]
- DEFRA [OD0221]
- European Research Council [242670]
- Biotechnology and Biological Sciences Research Council [BB/K004468/1, 1360457] Funding Source: researchfish
- BBSRC [BB/J014427/1, BB/K004468/1] Funding Source: UKRI
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The host epithelium is the critical interface with microbial communities, but the mechanisms by which the host regulates these communities are poorly understood. Here we develop the hypothesis that hosts use differential adhesion to select for and against particular members of their microbiota. We use an established computational, individual-based model to study the impact of host factors that regulate adhesion at the epithelial surface. Our simulations predict that host-mediated adhesion can increase the competitive advantage of microbes and create ecological refugia for slow-growing species. We show how positive selection via adhesion can be transformed into negative selection if the host secretes large quantities of a matrix such as mucus. Our work predicts that adhesion is a powerful mechanism for both positive and negative selection within the microbiota. We discuss molecules-mucus glycans and IgA-that affect microbe adhesion and identify testable predictions of the adhesion-as-selection model.
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