Journal
CELL HOST & MICROBE
Volume 20, Issue 6, Pages 709-715Publisher
CELL PRESS
DOI: 10.1016/j.chom.2016.10.021
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Funding
- BASF
- David and Lucile Packard Foundation
- DARPA [HR0011-15-C-0084]
- Program for Breakthrough Biomedical Research
- Investigators in the Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund
- NIH [DK101674]
- Division Of Mathematical Sciences
- Direct For Mathematical & Physical Scien [1563159] Funding Source: National Science Foundation
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Renal disease is growing in prevalence and has striking co-morbidities with metabolic and cardiovascular disease. Indoxyl sulfate (IS) is a toxin that accumulates in plasma when kidney function declines and contributes to the progression of chronic kidney disease. IS derives exclusively from the gut microbiota. Bacterial tryptophanases convert tryptophan to indole, which is absorbed and modified by the host to produce IS. Here, we identify a widely distributed family of tryptophanases in the gut commensal Bacteroides and find that deleting this gene eliminates the production of indole in vitro. By altering the status or abundance of the Bacteroides tryptophanase, we can modulate IS levels in gnotobiotic mice and in the background of a conventional murine gut community. Our results demonstrate that it is possible to control host IS levels by targeting the microbiota and suggest a possible strategy for treating renal disease.
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